The genetic disorder known as Down syndrome has been the subject of a study by researchers at Mei University in Japan, who have made progress in the study of chromosome 21 and its elimination.

As is known, Down syndrome “is a genetic disorder caused by the presence of an extra copy of chromosome 21, a phenomenon known as trisomy 21, which causes physical and cognitive alterations in those who suffer from it, such as heart defects, hearing loss, and difficulties in speech and learning development.”

At Mei University, scientists have applied a gene editing technique that could allow the complete elimination of the extra chromosome.

According to the PNAS Nexus publication, the scientists used “a tool called CRISPR-Cas9 to eliminate excess chromosomes in affected cells and return cell behavior to its normal function.”

This action aids in gene editing, which uses an enzyme to identify specific DNA sequences. “Once the enzyme finds a matching site, it selectively removes the extra copy of chromosome 21. This process, called allele-specific editing, allows the cutting enzyme to act only on the trisomy without affecting the rest of the genetic material.”

As a result, the group of scientists observed that gene expression normalized. Furthermore, the corrected cells accelerated their growth, with a shorter doubling time.

The discovery is a remarkable step toward controlling chromosome 21, which causes Down syndrome worldwide.

M.Pino

Source: actualidad.rt

(Reference image source: digitale.de on Unsplash)

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Bancamiga supports the work that the Venezuelan Association for Down Syndrome (Avesid) has carried out for more than three decades to improve the quality of life of people who suffer from an intellectual disability, through educational or assistance programs aimed at children, young people and adults.

The President of the Board of Directors of Bancamiga Banco Universal, José Simón Elarba, praised the constant work of Avesid and its commitment to the full inclusion of people with Down Syndrome, as well as to the development of their abilities.

“The work they do is impressive. We are all moved by being able to collaborate and make the work they do more viable, which truly helps people who need it,” he said.

To boost the potential and develop the skills of people with disabilities, Bancamiga provided a contribution that covers the cost of an Avesid project aimed at learning culinary skills for 35 young people, as well as creating a micro-enterprise for food and hydration services for events.

Bancamiga and Avesid with the sustainable development of the country

The Bo-K-2 project seeks to empower participants with work skills and train them as entrepreneurs, promoting social and labor inclusion.

María Susana Padrón de Grasso, president of Avesid, explained that the project offers young people the opportunity to train and “obtain resources, contribute to their home and feel like useful people, who have a job and that there is room for everyone.”

With the contribution of Bancamiga, Avesid will have the necessary resources to carry out theoretical and practical workshops, where young people with disabilities will learn culinary techniques, hygiene and food safety standards, menu planning, as well as management of catering businesses, among other aspects.

The initiative “began with the preparation of some wonderful recipes. Now we are going to make recipes with a higher level, which we will offer to the public who wants to help,” said Padrón de Grasso.

Bancamiga’s social responsibility management focuses on contributing to the sustainable development of the country, with the purpose of benefiting the greatest number of people and positively impacting the environment.

With information and reference image provided by Bancamiga Banco Universal and Avesid

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